The present study aims to conduct a genealogical analysis of Verse 83 of Surah An-Nisa and its complementary verses, with the goal of deriving a theoretical framework entitled “Islamic Epistemic Governance.” This article addresses the central question of how the Qur’anic model of information management, with a focus on the development of the concepts of “Uli al-Amr” (those in authority) and “Mustanbitin” (the ones who derive knowledge), structures the relationship between power and knowledge, and what principles it provides for confronting contemporary information crises. For this purpose, using a dual qualitative approach that includes content analysis of exegeses and Foucauldian critical genealogy, the evolution of discourses in this field has been examined. The findings indicate that the understanding of “Uli al-Amr” has evolved throughout history from an executive authority to an epistemic authority. Moreover, the Qur’anic information system is based on four principles: universal responsibility and verification, reference to a dynamic authority, specialized inference, and the fundamental role of faith in providing protection. The ultimate outcome is the presentation of a framework for Islamic Epistemic Governance, a model in which the legitimacy of power is linked to the wise management of knowledge for ensuring the security and guidance of the Ummah, and which, with an emphasis on value-based foundations, possesses the capacity to address contemporary information challenges.